Mancuso, F.B.I. is an American crime drama television series created by Steve Sohmer, which was aired by NBC from October 13, 1989 to April 24, 1990, as part of its 1989–90 schedule.

Mancuso, F.B.I. stars Robert Loggia as Nick Mancuso, a hardened veteran of the Bureau now assigned to Washington, D.C., where he was largely regarded by his superiors and bureaucratic types as a maverick with little regard for agency rules and procedures. This charge was largely true; Mancuso's true motivation was, as a press release for the show near the time of its premiere described it, "a ionate love affair with the United States Constitution" and an overwhelming desire to see genuine justice rather than the mere appearance of it.